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FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, <t>valerylfentanyl,</t> and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).
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FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, <t>valerylfentanyl,</t> and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).
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FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, <t>valerylfentanyl,</t> and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).
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FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, <t>valerylfentanyl,</t> and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).
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item no 23085  (Cayman Chemical)
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FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, <t>valerylfentanyl,</t> and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).
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item no 23083  (Cayman Chemical)
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Cayman Chemical item no 23083
FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, <t>valerylfentanyl,</t> and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).
Item No 23083, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, valerylfentanyl, and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).

Journal: Drug testing and analysis

Article Title: Influence of carbon side chain length on the in vivo pharmacokinetic and pharmacodynamic characteristics of illicitly manufactured fentanyls.

doi: 10.1002/dta.3636

Figure Lengend Snippet: FIGURE 2 Time course effects of IMFs on tail flick response. IMFs were dosed at 300 μg/kg sc. Control animals received saline vehicle (300 μl/kg, sc). (a) Significantly different than acetylfentanyl, valerylfentanyl, and saline treatment groups (p < 0.01); (b) significantly different than valerylfentanyl and saline treatment group (p < 0.05); (c) significantly different than saline treatment group (p < 0.05); (d) significantly different from all other treatment groups (p < 0.05, Tukey's post hoc). Data are expressed as %MPE mean ± SEM (n = 5–6 animals).

Article Snippet: Fentanyl hydrochloride, acetylfentanyl hydrochloride, butyrylfentanyl hydrochloride, cyclopropylfentanyl hydrochloride, and valerylfentanyl hydrochloride for animal experiments were all purchased from Cayman Chemical Company (Ann Arbor, MI).

Techniques: Tail Flick Test, Control, Saline

FIGURE 3 Time course effects of IMFs on body temperature. IMFs were dosed at 300 μg/kg sc. Control animals received saline (300 μl/kg, sc). Body temperature data are changed from baseline. (a) Significantly different than all other groups (p < 0.0001); (b) significantly different than acetylfentanyl and valerylfentanyl treatment groups (p < 0.01); (c) significantly different than acetylfentanyl, butyrylfentanyl, valerylfentanyl, and saline treatment groups (p < 0.001); (d) significantly different than butyrylfentanyl, cyclopropylfentanyl, and fentanyl treatment groups (p < 0.0001); (e) significantly different from acetylfentanyl, valerylfentanyl, and saline treatment groups (p < 0.001, Tukey's post hoc). Data are expressed as mean ± SEM for n = 5–6 rats per treatment group.

Journal: Drug testing and analysis

Article Title: Influence of carbon side chain length on the in vivo pharmacokinetic and pharmacodynamic characteristics of illicitly manufactured fentanyls.

doi: 10.1002/dta.3636

Figure Lengend Snippet: FIGURE 3 Time course effects of IMFs on body temperature. IMFs were dosed at 300 μg/kg sc. Control animals received saline (300 μl/kg, sc). Body temperature data are changed from baseline. (a) Significantly different than all other groups (p < 0.0001); (b) significantly different than acetylfentanyl and valerylfentanyl treatment groups (p < 0.01); (c) significantly different than acetylfentanyl, butyrylfentanyl, valerylfentanyl, and saline treatment groups (p < 0.001); (d) significantly different than butyrylfentanyl, cyclopropylfentanyl, and fentanyl treatment groups (p < 0.0001); (e) significantly different from acetylfentanyl, valerylfentanyl, and saline treatment groups (p < 0.001, Tukey's post hoc). Data are expressed as mean ± SEM for n = 5–6 rats per treatment group.

Article Snippet: Fentanyl hydrochloride, acetylfentanyl hydrochloride, butyrylfentanyl hydrochloride, cyclopropylfentanyl hydrochloride, and valerylfentanyl hydrochloride for animal experiments were all purchased from Cayman Chemical Company (Ann Arbor, MI).

Techniques: Control, Saline